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447 matching studies
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Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
Massachusetts General Hospital
Gout
The TRUST study is a randomized, controlled multicenter study to evaluate the management
of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to
determine the most beneficial for a patient-centered gout outcomes, as well as relevant
cardiovascular-metabolic-renal endp1 expand
The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered gout outcomes, as well as relevant cardiovascular-metabolic-renal endpoints. Type: Interventional Start Date: Feb 2024 |
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The Osteoarthritis Prevention Study
Wake Forest University
Osteoarthritis, Knee
The goal of this study is to establish the efficacy of an intervention of dietary weight
loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in
adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary
aim is to compare the effects of a d1 expand
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention. Type: Interventional Start Date: Mar 2024 |
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Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
Brigham and Women's Hospital
Opioid Use
Pain
Hypogonadism, Male
The aim of this trial is to evaluate whether testosterone replacement results in greater
improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of
life when compared with placebo in men with chronic spinal pain treated with opioids who
have opioid-induced hypogonadism1 expand
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism (low testosterone). Type: Interventional Start Date: Jan 2022 |