TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
Purpose
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.
Condition
- Cardiovascular Diseases
Eligibility
- Eligible Ages
- Over 20 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Aged greater than 20 years - Undergoing aortic valve surgery with or without CABG surgery - Receive and apical vent as part of the surgery
Exclusion Criteria
- Will not receive an apical left ventricular vent
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Recruiting Locations
Brigham and Women's Hospital
Boston 4930956, Massachusetts 6254926 02115
Boston 4930956, Massachusetts 6254926 02115
More Details
- Status
- Recruiting
- Sponsor
- Brigham and Women's Hospital