Developing Fast Pediatric Imaging

Purpose

This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images

Condition

  • Pediatric Low-grade Gliomas

Eligibility

Eligible Ages
Over 0 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Infants, children and adults who have been diagnosed with Low Grade Glioma - Healthy volunteers - Children from age 0 to adults with no upper age limit or; - Diagnosed with LGG and being treated at DFCI;

Exclusion Criteria

  • Electrical implants such as cardiac pacemakers or perfusion pumps; - Ferromagnetic implants such as aneurysm clips, surgical clips, prosthesis, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants; - Ferromagnetic objects such as jewelry or metal clips; - Women of childbearing age who are seeking to become pregnant, who are breastfeeding, or who suspect they may be pregnant; - Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions; - Any greater than normal potential for cardiac arrest

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Diagnostic
Masking
Single (Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Primary Testing Group 		- This scan is in the same imaging session as the participant's scheduled clinical MRI and is no longer 15 minutes - Wave-CAIPI will be use to enable a 40-60 s acquisition per contrast at 0.9-mm isotropic resolution - Wave-CAIPI will be used to acquire a 4-echo GE-SE time-series at 1.5-mm isotropic resolution
  • Other: Wave-CAIPI
    "wave-CAIPI" technology, a data acquisition / reconstruction scheme designed to optimally exploit available information in modern multi-channel receivers and in multi-contrast/time-series data for improved image encoding
Experimental
Software Testing Group 		- Participants will receive hour research-only scan - Wave-CAIPI will be use to enable a 40-60 s acquisition per contrast at 0.9-mm isotropic resolution - Wave-CAIPI will be used to acquire a 4-echo GE-SE time-series at 1.5-mm isotropic resolution
  • Other: Wave-CAIPI
    "wave-CAIPI" technology, a data acquisition / reconstruction scheme designed to optimally exploit available information in modern multi-channel receivers and in multi-contrast/time-series data for improved image encoding

Recruiting Locations

Boston Children Hospital
Boston, Massachusetts 02215
Contact:
Susan N Chi, MD
617-632-3000
schi@partners.org

Dana Farber Cancer Institute
Boston, Massachusetts 02215
Contact:
Susan N Chi, MD
617-632-3000
schi@partners.org

More Details

Status
Recruiting
Sponsor
Boston Children's Hospital

Study Contact

Kawin Setsompop, PhD
617-669-6640
kawin@nmr.mgh.harvard.edu

Detailed Description

The purpose of the study is to develop new technologies for MRI systems. The new technologies should improve MRI capabilities in terms of how sensitive, specific, and efficient they are. The overall goal is to get better measurements of the brain tumor tissue(s). In this research study, the investigators want to learn more about investigational software and about techniques to process MR images. The testing of investigational software will allow the investigators to improve the image quality. As part of the testing process, the investigators will collect more MR images of the brain, and improve current image reconstruction methods. This will allow a more precise analysis of MR images and potentially better assessment of the brain tumor tissue volume.