Dietary Intervention to Mitigate Adverse Consequences of Night Work
Purpose
The goal of this clinical trial is to test whether our dietary intervention can prevent or lessen the negative health effects of night shift work in healthy participants. Participants will: - complete 2 inpatient stays - be provided with identical meals - have frequent blood draws - provide urine, saliva, stool and rectal swab samples
Condition
- Dietary Habits
Eligibility
- Eligible Ages
- Between 18 Years and 45 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- 18-45 yr old - BMI 20.0-29.9 - European/Hispanic/African-American ancestry - No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
Exclusion Criteria
- Currently smoking/vaping or 5 or more years of smoking/vaping - History of drug or alcohol dependency - History of psychiatric illness or disorder
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Control-Dietary Intervention |
Control condition first, then the Dietary intervention. Since this is a single blind study, the details of the dietary interventions cannot be released during recruitment stage but will be made public once enrollment closes. |
|
|
Experimental Dietary intervention-Control |
Dietary intervention first, then the Control condition. Since this is a single blind study, the details of the dietary interventions cannot be released during recruitment stage but will be made public once enrollment closes. |
|
Recruiting Locations
Boston, Massachusetts 02115
Han-Chow Koh, PhD
617-278-0924
More Details
- Status
- Recruiting
- Sponsor
- Brigham and Women's Hospital
Detailed Description
Shift work increases the risk for diabetes possibly due to the adverse metabolic effects of circadian misalignment. As shift work is not foreseen to disappear, the development of individually-targeted therapies for metabolic health in these vulnerable shift workers is urgently needed. This research will determine whether our dietary intervention can mitigate the adverse metabolic effects of circadian misalignment, which may help in the design of evidence-based dietary interventions to improve the metabolic health in shift workers.