Menstrual-phase-dependent Differences in Response to Sleep Loss
Purpose
This study is designed to assess how healthy premenopausal women respond to different patterns of sleep loss at different times in the menstrual cycle.
Condition
- Sleep Deprivation
Eligibility
- Eligible Ages
- Between 18 Years and 35 Years
- Eligible Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Female - 18-35 years old - Regular menstrual cycle between 26-35 days in duration - Not using any form of hormonal contraception for at least the prior 3 months - Regular sleep patterns (7-9 hours/night) - Not taking any medications or supplements - Weight >110 lb - BMI between 18.5 and 29.5 kg/m2
Exclusion Criteria
- Primary sleep disorder - History of shift work - Transmeridian travel in the previous 3 months - Presence of acute or chronic disease, including but not limited to: diabetes, metabolic disorders, psychiatric illness, reproductive disorders - Current pregnancy, < 6 months postpartum, and/or breastfeeding - Blood donation in the past 8 weeks - Extreme morning or evening chronotype
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
- Masking Description
- Participants may not know to which study arm they are assigned.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Chronic variable sleep deficiency - follicular phase |
This will be the first of four arms of controlled sleep manipulation. Participants randomized to this arm will be studied on a chronic variable sleep deficiency schedule during the follicular phase of their menstrual cycle. The exact sleep schedule is not provided in order to keep participants blinded to sleep conditions. |
|
|
Experimental Chronic variable sleep deficiency - luteal phase |
This will be the second of four arms of controlled sleep manipulation. Participants randomized to this arm will be studied on a chronic variable sleep deficiency schedule during the luteal phase of their menstrual cycle. The exact sleep schedule is not provided in order to keep participants blinded to sleep conditions. |
|
|
Experimental Control sleep - follicular phase |
This will be the third of four arms of controlled sleep manipulation. Participants randomized to this arm will be studied on a control sleep schedule during the follicular phase of their menstrual cycle. The exact sleep schedule is not provided in order to keep participants blinded to sleep conditions. |
|
|
Experimental Control sleep - luteal phase |
This will be the fourth of four arms of controlled sleep manipulation. Participants randomized to this arm will be studied on a control sleep schedule during the luteal phase of their menstrual cycle. The exact sleep schedule is not provided in order to keep participants blinded to sleep conditions. |
|
Recruiting Locations
Brigham and Women's Hospital
Boston, Massachusetts 02115
Boston, Massachusetts 02115
More Details
- Status
- Recruiting
- Sponsor
- Brigham and Women's Hospital
Detailed Description
During a 1.5-week inpatient laboratory protocol, participants will undergo one of two parallel sleep conditions during either the follicular or luteal phase of the menstrual cycle (4 study arms total). Subjects will be randomly assigned to each study arm. During their time in the laboratory, biological samples (e.g., blood) will be collected for assessment of sex steroid hormones and other analyses. Sleep quantity and quality will be monitored and responses on neurobehavioral tests and surveys will be monitored for differences across conditions.