Effect of Physical Activity Pattern on Cardiometabolic Health
Purpose
The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: - complete 2 inpatient stays - perform moderate exercise - be provided with identical meals - have frequent blood draws - provide urine and saliva samples
Condition
- Life Style
Eligibility
- Eligible Ages
- Between 18 Years and 45 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- 18-45 yr old - Body mass index (BMI) 25-34.9 kg/m2 - No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.) - Willing to adhere to the protocol requirements for the duration of the study
Exclusion Criteria
- Currently smoking/vaping or 5 or more years of smoking/vaping - Currently pregnant or breastfeeding - History of drug or alcohol dependency - History of psychiatric illness or disorder - Any hospitalization due to COVID-19 - Inability to exercise for any reason - Any known contraindication to exercise testing based on current ACSM guidelines
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Exercise A-B Intervention |
The Exercise A first, then the Exercise B intervention. |
|
|
Experimental Exercise B-A Intervention |
The Exercise B first, then the Exercise A intervention. |
|
Recruiting Locations
Boston, Massachusetts 02115
More Details
- Status
- Recruiting
- Sponsor
- Brigham and Women's Hospital
Detailed Description
The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.