The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
Purpose
Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.
Conditions
- Rheumatoid Arthritis (RA
- Atherosclerotic Cardiovascular Disease (ASCVD)
Eligibility
- Eligible Ages
- Between 35 Years and 79 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- RA diagnosed by a rheumatologist - Age 40- 79 - ≥1 ASCVD risk factor including prediabetes, hypertension, BMI >30, current or history of cigarette smoking
Exclusion Criteria
- Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor - Patients with diabetes mellitus - Pregnancy
Study Design
- Phase
- Study Type
- Observational [Patient Registry]
- Observational Model
- Cohort
- Time Perspective
- Cross-Sectional
Recruiting Locations
Brigham and Womens Hospital
Boston 4930956, Massachusetts 6254926 02115
Boston 4930956, Massachusetts 6254926 02115
More Details
- Status
- Recruiting
- Sponsor
- Brigham and Women's Hospital
Study Contact
Detailed Description
The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.