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Purpose

This multinational, investigator-initiated registry aims to investigate clinical outcomes of patients undergoing transcatheter mitral valve replacement (TMVR). The registry primarily focuses on patients treated with TMVR in real-world clinical practice. Patients evaluated for TMVR but not undergoing the procedure are no longer systematically included. Historical data may include such patients who subsequently underwent alternative treatments, including transcatheter edge-to-edge repair, mitral valve surgery, or medical/conservative therapy.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • clinically significant mitral insufficiency - patient underwent screening for TMVI - echocardiography data at baseline (and after TMVI, E2E and surgery) - follow-up of at least 30 days

Exclusion Criteria

  • age under 18 years

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Retrospective

Arm Groups

ArmDescriptionAssigned Intervention
Transcatheter Mitral Valve Replacement (TMVR) Patients with successful TMVR screening, who underwent Transcatheter Mitral Valve Replacement subsequently. All devices may be included.
Mitral transcatheter edge-to-edge repair (M-TEER) Patients with TMVR screening failure, who subsequently underwent interventional mitral valve edge-to-edge repair. Update: These patients are currently no longer systematically included.
Mitral valve surgery (Surgery) Patients with TMVR screening failure, who subsequently underwent mitral valve surgery (i.e., mitral valve repair or replacement). Update: These patients are currently no longer systematically included.
Medical/conservative therapy Patients with TMVR screening failure, who subsequently underwent conservative or optimal medical therapy. Update: These patients are currently no longer systematically included.

Recruiting Locations

Brigham and Women's Hospital
Boston, Massachusetts 02115
Contact:
Tsuyoshi Kaneko, MD

More Details

Status
Recruiting
Sponsor
Universitätsklinikum Hamburg-Eppendorf

Study Contact

Sebastian Ludwig, MD
+494074100
se.ludwig@uke.de

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.